Overview

As a leading global animal health company, Elanco delivers innovative products and services to improve the health of pets and farm animals around the world because we believe making animals’ lives better, makes life better. Since 1954, we have provided solutions that support veterinarians, farmers and pet owners to advance our vision of Food and Companionship Enriching Life. Elanco’s promise to employees: Together, we foster an inclusive culture where everyone can make a difference, encouraging ownership, growth and well-being.

 

Elanco Animal Health is looking for a structural bioinformatics scientist to join a growing interdisciplinary global informatics team. The ideal candidate will possess broad knowledge of molecular modeling tools and techniques and will work both as a project consultant and as a thought leader for discovery biology teams in vaccines, and biotherapeutics. The primary technical focus will be development and application of structural bioinformatics and molecular modeling solutions to support both early development of biotherapeutic products. This position sits in the computational sciences hub of the Elanco Research & Breakthrough Innovation, a multi-disciplinary core focused on discovery and early phase research programs. In this role, you will be expected to:

  • Apply protein design, sequence analysis, structure prediction, modeling, and molecular dynamics approaches to analyze and predict biophysical properties and other structure-property relationships of proteins
  • Work closely with cross-functional teams across Elanco and its external collaborators to support structure-based design of therapeutic peptides, proteins, and antibodies
  • Develop computational strategies to guide the design of biotherapeutics with improved biological properties and developability characteristics
  • Acquire or develop computational tools for predicting liabilities and biophysical properties that impact biopharmaceutical product safety and developability
  • Implement or support informatics solutions for molecule registration, protein engineering and production workflows, and data distribution and analysis
  • Perform structure prediction activities on peptides, proteins, protein-ligand and protein-protein complexes (homology modeling, threading, ab initio modeling)
  • Manage multiple experiments, projects, and interactions with supporting functions
  • Participate in the development of protein engineering methodologies
  • Develop and apply computational strategies for optimization of biotherapeutics
  • Communicate effectively with internal and external collaborators
  • Attend and present your work at scientific conferences
  • Actively participate in global communities of practice at Elanco

 

Basic Minimum Qualifications:

  • Ph.D. in relevant life sciences or computational sciences domain (e.g. molecular biology, bioinformatics, structural biology, chemistry, physics, computer science)
  • Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner
  • Demonstrated ability to work with highly skilled teams in a fast-paced, highly collaborative, entrepreneurial, and technical setting
  • Strong time management and problem-solving skills
  • This role heavily requires expertise in protein redesign, structure prediction, docking, and sequence analyses. We are particularly interested in candidates with prior experience in structure-based protein design (Rosetta) and AI powered tools (RosettaFold, AlphaFold etc)
  • Demonstrated experience with protein modeling tools for structure prediction, visualization, and protein design (e.g. Schrodinger, MOE, Rosetta)
  • Expertise in principles of protein structure and structure-function relationships
  • Qualified candidates must be legally authorized to be employed in the United States. Elanco does not anticipate providing sponsorship for employment visa status (e.g., H-1B or TN status) for this employment position.

 

Preferred Qualifications:

  • 3 years postgraduate experience preferred
  • Familiarity with experimental & empirical approaches (ideally high throughput) for testing computational protein predictions (i.e. must be able to interface with these experimental teams).
  • Experience in development and application of molecular dynamics methods, and familiarity with common software platforms (e.g. GROMACS)
  • Familiarity with small molecule docking, library screening, and discovery (Schrodinger).
  • Experience with common workflow automation, scripting, and programming platforms (e.g. Python)
  • Familiarity with cloud HPC environments (Azure, AWS, Google)
  • Ability to work as an independent contributor/consultant on global, interdisciplinary teams driving biopharmaceuticals research
  • Ability to work closely with colleagues in genomics, bioinformatics, cheminformatics, data analytics, and scientific computing to develop and implement long-term informatics strategies in key functional areas
  • Programming/scripting expertise as required for developing and optimizing computational methods, workflow automation, and data analysis
  • A record of scientific leadership and innovation as demonstrated by publications, presentations, and/or patents
  • Ability to travel globally up to 10% of the time

 

Elanco is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status

Tagged as: EARLY CAREER, MID TO SENIOR LEVEL

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